Small Peptides Activate the Latent Sequence-Specific DNA Binding Function of ~53
نویسندگان
چکیده
منابع مشابه
Identification of an additional negative regulatory region for p53 sequence-specific DNA binding.
The DNA binding activity of p53 is crucial for its tumor suppressor function and is subject to tight regulation. Previous studies revealed that the inhibitory function of the p53 C terminus is implicated in the latent, low affinity sequence-specific DNA binding activity of p53 in the uninduced state. Sequence-specific DNA binding of p53 has been shown to be activated by several posttranslationa...
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